| 白细胞介素-18在急性移植物抗宿主病发病机制中的作用 |
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| 引用本文： | 居小萍,王健民,侯军,冯曹波,童书鹏,章卫平. 白细胞介素-18在急性移植物抗宿主病发病机制中的作用[J]. 中国实验血液学杂志, 2002, 10(5): 452-454 |
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| 作者姓名： | 居小萍 王健民 侯军 冯曹波 童书鹏 章卫平 |
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| 作者单位： | 第二军医大学附属长海医院血液科,上海,200433 |
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| 基金项目： | 国家自然科学基金 (编号 39870 710 )，上海市卫生系统百人计划基金 (编号98BR0 2 9)资助项目 |
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| 摘 要： | 为了研究异基因外周血造血干细胞(allo—PBSCT)移植期细胞因子白细胞介素—18(IL—18)与急性移植物抗宿主病(aGVHD)的关系，以探讨IL—18在aGVHD发病中的作用，对26例恶性血液病患进行了allo—PBSCT，并采用双夹心酶联免疫吸附法(ELISA)检测移植前及移植后aGVHD发生时患外周血单个核细胞分泌的IL—18浓度。结果表明：移植患中10例发生I度GVHD和5例发生Ⅲ—Ⅳ度GVHD，发生aGvHD患分泌的IL—18浓度显高于未发生aGVHD患，并又IL—18浓度与aGVHD的严重程度成正相关，与感染的发生无关。结论：IL—18在aGVHD的发病中起重要的作用。
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| 关 键 词： | 异基因外周血干细胞移植 急性移植物抗宿主病 白细胞介素—18 白血病 发病机制 |
| 修稿时间： | 2001-09-05 |
Role of Interleukin-18 in Pathogenesis of Acute Graft-Versus-Host Disease |
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| JU Xiao Ping,WANG Jian Min,HOU Jun,FENG Cao Bo,TONG Shu Peng,ZHANG Wei Ping. Role of Interleukin-18 in Pathogenesis of Acute Graft-Versus-Host Disease[J]. Journal of experimental hematology, 2002, 10(5): 452-454 |
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| Authors: | JU Xiao Ping WANG Jian Min HOU Jun FENG Cao Bo TONG Shu Peng ZHANG Wei Ping |
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| Affiliation: | Department of Hematology, The Affiliated Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. |
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| Abstract: | To investigate the relationship between interleukin-18 (IL-18) and human acute graft-versus-host disease (aGVHD), 26 patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were included in this study. IL-18 secreted by peripheral blood mononuclear cells (MNCs) was measured by enzyme-linked immunosorbent assay (ELISA) before transplantation and during aGVHD. The results showed that grade I GVHD and grades III-IV GVHD developed in 10 and 5 cases, respectively. The levels in the supernatants of MNCs from patients with aGVHD were significantly higher than those in the cases without aGVHD. The levels of IL-18 were correlated with the severity of aGVHD. It is concluded that IL-18 plays an important role in the development of aGVHD. |
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| Keywords: | allogeneic peripheral blood stem cell transplantation acute graft versus host disease interleukin 18 leukemia |
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