| 乳腺癌EGFR、p16蛋白表达与预后的关系 |
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| 引用本文： | 吕彧,赵宏颖,唐小奈. 乳腺癌EGFR、p16蛋白表达与预后的关系[J]. 临床与实验病理学杂志, 2002, 18(3): 271-272 |
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| 作者姓名： | 吕彧 赵宏颖 唐小奈 |
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| 作者单位： | 首都医科大学附属北京朝阳医院病理科,北京,100020 |
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| 摘 要： | 目的 :研究EGFR和 p16蛋白在人乳腺癌中表达及其与预后关系。 方法 :用免疫组化LSAB法 ,检测 5 4例乳腺癌中EGFR和p16蛋白的表达情况 ,并用HPLAS - 10 0 0高清晰度彩色病理图文分析系统进行定量测定。 结果 :EGFR的表达强度在乳腺癌组织学分级、淋巴结转移和预后方面差异有显著性 (P <0 0 5 ) ;p16蛋白与乳腺癌预后之间有差异 (P <0 0 5 )。结论 :检测EGFR和 p16蛋白对判断乳腺癌预后有重要意义
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| 关 键 词： | 乳腺肿瘤 EGFR 蛋白质p16 免疫组织化学 预后 |
| 文章编号： | 1001-7399(2002)03-0271-02 |
| 修稿时间： | 2000-09-25 |
The expression of EGFR, p16 protein and prognosis of breast cancers |
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| Abstract: | Purpose To study the relationship between the expression of EGFR,p16 protein and prognosis of breast cancers. Methods Immunohistochemical staining for EGFR and p16 protein was performed in 54 cases of breast cancers,HPLAS- 1000 image software was used to analyze staining result.Results The expression of EGFR was related to the histological grade,lymphatic metastasis and prognosis(P<0.05). The expression of p16 protein was related to prognosis(P<0.05). Conclusion The detection of EGFR, p16 protein have an important significance on prognosis for breast cancers. |
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| Keywords: | breast neoplasms EGFR proteins p16 immunohistochemistry prognosis |
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