| 蝮蛇抗栓酶对离体工作员心缺血再灌注损伤的保护作用 |
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| 引用本文： | 刘金保,欧阳静萍,涂淑珍,杨海鹭,董传仁. 蝮蛇抗栓酶对离体工作员心缺血再灌注损伤的保护作用[J]. 广州医学院学报, 1991, 0(1) |
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| 作者姓名： | 刘金保 欧阳静萍 涂淑珍 杨海鹭 董传仁 |
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| 作者单位： | 广州医学院病生教研室，湖北医学院病生教研室，湖北医学院病生教研室，湖北医学院病生教研室，湖北医学院病生教研室 |
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| 摘 要： | 本实验采用Langendorff离体心脏灌流模型,观察了大鼠心肌缺血(15cm H_2O,20 min)再灌注(70cm H_2O,30 min)后心肌的机能、代谢改变及蝮蛇抗栓酶对其影响。实验分为单纯缺血再灌注组(I-R组)和蝮蛇抗栓酶治疗组(A.H组,灌流液中加入A.H 2.5 u/L)。结果发现,A.H组心肌游离脂肪酸(FFA)降低,磷脂(PL)含量高于I-R组;心肌脂质过氧化物(LPO)含量降低,锰-超氧化物歧化酶(Mn-SOD)及谷胱甘肽过氧化物酶(GSH-Px)活力高于I-R组。结果提示,A.H在体外具有较强的抗自由基损伤、保护抗氧化酶活性和稳定细胞膜的作用。
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| 关 键 词： | 蝮蛇抗栓酶 心肌缺血再灌注 氧自由基 工作鼠心 |
Protective Effects of A. Halys on Myocardial Damage in Isolated Working Rat Heart after Ischemia-reperfusion |
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| Liu Jjnbao. Protective Effects of A. Halys on Myocardial Damage in Isolated Working Rat Heart after Ischemia-reperfusion[J]. Academic Journal of Guangzhou Medical College, 1991, 0(1) |
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| Authors: | Liu Jjnbao |
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| Affiliation: | Liu Jjnbao Department of Pathophysiology |
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| Abstract: | The functional and metabolic changes in isolated working rat heart following myocardial ischemia (15cm H_2O, 20min) and reperfusion (70cm H_2O, 30min), and the effect of A.Halys on the above changes were observed in the Langendorff Heart Model. The study was divided into two groups: ischemia - reperfusion group (I- R group) and A.Halys-treated group (A.H group, with addition of A.Halys 2.5U/L).The results showed there were decreases in FFA, MDA contents and increases in phospholipid contents, and Mn-SOD and GSH-Px activities in the A.H group, as compared with the 1-R group. The results suggested that A.Halys had a beneficial effect on ischemic myocardium, as indicated by tle inactivation of lipid peroxides, and an increase of antioxidant enzyme activities and the stabilization of cell membrane. |
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| Keywords: | A.halys myocardial ischemia-reperfusion oxygen free radicals or OFR working rat heart |
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