| 广州地区产AmpC酶肺炎克雷伯菌耐药性及氨基糖苷类修饰酶基因分析 |
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| 引用本文： | 叶惠芬,陈惠玲,周小棉,张晓洁.广州地区产AmpC酶肺炎克雷伯菌耐药性及氨基糖苷类修饰酶基因分析[J].江西医学检验,2008(5):473-474. |
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| 作者姓名： | 叶惠芬 陈惠玲 周小棉 张晓洁 |
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| 作者单位： | 广东省广州市第一人民医院; |
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| 基金项目： | 广东省医学科研基金资助(A2005537); 广州市科技攻关项目(2006ZI-E0141) |
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| 摘 要： | 目的调查广州地区临床分离产AmpC酶肺炎克雷伯菌对抗菌药物耐药性及氨基糖苷类修饰酶基因分布。方法采用纸片扩散法（即K-B法）测定51株产AmpC肺炎克雷伯菌对15种抗菌药物的耐药情况，聚合酶链反应（PCR）分析ampC和氨基糖苛修饰酶基因型。结果51株产AmpC肺炎克雷伯菌呈现多重耐药，对阿米卡星、庆大霉素、妥布霉素和奈替米星的耐药率分别为39.2％、66.7％、58.8％和43.1％，除亚胺培南外其余抗生素耐药率在47.0％-100％；41株（80.3％）检出氨基糖苷修饰酶基因。结论临床分离的产AmpC酶肺炎克雷伯菌多重耐药严重，氨基糖苷修饰酶基因携带率很高。
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| 关 键 词： | 肺炎克雷伯菌 氨基糖苷修饰酶基因 耐药性 |
Analysis on the resistance and genotype of aminoglycoside modifying enzymes in AmpC- producing Klebsiella pneumonia from Guangzhou area |
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| YE Huifen,CHEN Huilin,ZHOU Xiaomian,et al..Analysis on the resistance and genotype of aminoglycoside modifying enzymes in AmpC- producing Klebsiella pneumonia from Guangzhou area[J].Jiangxi Journal of Medical Laboratory Sciences,2008(5):473-474. |
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| Authors: | YE Huifen CHEN Huilin ZHOU Xiaomian |
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| Institution: | YE Huifen,CHEN Huilin,ZHOU Xiaomian,et al. The First Municipal People\'s Hospital of Guangzhou,Guangzhou 510180,China |
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| Abstract: | Objective To investigate the resistance and genotype of aminoglycoside modifying enzymes in AmpC-producing Klebsiella pneumonia from Guangzhou area. Methods Kirby-Bauer tests were performed to detect the susceptibility of 15 kinds of antimicrobial agents against 51 strains of AmpC-producing Klebsiella pneumonia, AmpC and aminoglycoside modifying enzymes genes were detected by PCR method. Results The 51 strains were exhibited multiple drug-resistance . The resistant rates to Amikacin,Gentamicin , Tobramycin ... |
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| Keywords: | Klebsiella pneumonia Aminoglycoside modifying enzymes Gene |
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