| 祛痰活性物质——鹃花醇(Matteucinol)的合成 |
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| 引用本文： | 谢晶曦,王琳,刘春雪,葛大伦.祛痰活性物质——鹃花醇(Matteucinol)的合成[J].中国医学科学院学报,1986(2). |
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| 作者姓名： | 谢晶曦 王琳 刘春雪 葛大伦 |
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| 作者单位： | 中国医学科学院药物研究所 北京
(谢晶曦，王琳，刘春雪)，中国医学科学院药物研究所 北京(葛大伦) |
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| 摘 要： | 本文报道了5,7-二羟基-6,8-二甲基-4′-甲氧基-TA氢黄酮(Ⅰ)(Mnt?eucinol鹃化醇)的合成,合成品为消旋体。小鼠酚红法药理试验表明具有与杜鹃素相类似的祛痰活性。
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| 关 键 词： | 鹃化醇 双氢黄酮 祛痰成份 |
Synthesis of Expectorant Principle of Natural Flavanone, "Matteucinol" |
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| Xie Jingxi,Wang Lin. Liu Chunxue and Ge Dalun.Synthesis of Expectorant Principle of Natural Flavanone, "Matteucinol"[J].Acta Academiae Medicinae Sinicae,1986(2). |
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| Authors: | Xie Jingxi Wang Lin Liu Chunxue and Ge Dalun |
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| Abstract: | Farrerol (4',5,7-trihydroxy-6 ,8-dimettylflavarcne) , an expectorant principle isolated from leaves of Rhododendron dauricum L, was first used to treat chronic bronchitis clinically. 4'-methyl-farrerol(I, Matteucinol)had been isolated from R. Simsii Planch by previous investigators. But its biological activities were not reported. Matteucinol (I) was synthesized and chara~ cterized by elemental analysis as well as IR, NMR and Mass spectroscopy, being found to be identical with the natural specimen. Pharmacological test shewed that the synthetic matteucinol (I) exhibited similar expectorant activity as that of farrerol by the mouse phenol red method. |
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| Keywords: | Matteucinol Flavanone Expectorant principle |
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