| 32P照射对HL-60细胞增殖周期的影响 |
| |
| 引用本文： | 何子毅,孟庆勇.32P照射对HL-60细胞增殖周期的影响[J].南方医科大学学报,2005,25(2):198-200. |
| |
| 作者姓名： | 何子毅 孟庆勇 |
| |
| 作者单位： | 广东医学院分析中心, 广东, 湛江, 524023 |
| |
| 摘 要： | 目的 观察32P照射对HL-60细胞周期的影响。方法 不同剂量32P体外照射HL-60细胞24、48和72h,流式细胞法检测细胞周期。结果 不同剂量32P照射HL-60细胞对细胞周期有明显影响,首先发生G2/M期阻滞;随剂量增大,G2/M期和S期均发生阻滞,以G2/M期阻滞为主。结论 32P体外照射HL-60细胞对细胞周期有明显的干扰作用。
|
| 关 键 词： | 磷放射性同位素 细胞周期 HL-60细胞 |
| 文章编号： | 1000-2588(2005)02-0198-03 |
| 修稿时间： | 2004年8月15日 |
Effect of 32P irradiation on cell cycle of HL-60 cells |
| |
| HE Zi-yi,MENG Qin-yong.Effect of 32P irradiation on cell cycle of HL-60 cells[J].Journal of Southern Medical University,2005,25(2):198-200. |
| |
| Authors: | HE Zi-yi MENG Qin-yong |
| |
| Abstract: | Objective To investigate the effect of 32P irradiation on the cell cycle of HL-60 cells. Methods Flow cytometry was employed to detect cell cycle changes of HL-60 cells induced by 32P irradiation at different doses for varied time lengths (24, 28 and 72 h, respectively). Result 32P could induce cell cycle arrest in S and G2/M phases, and the arrest occurred initially in G2/M phase. Conclusion 32P may significantly interfere with the cell cycle of HL-60 cells, causing cell cycle arrest primarily in G2/M. |
| |
| Keywords: | phosphorus radioisotopes cell cycle HL-60 cells |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《南方医科大学学报》浏览原始摘要信息 |
| 点击此处可从《南方医科大学学报》下载免费的PDF全文 |
|
