| 盐酸关附甲素注射液对实验性心律失常的作用 |
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| 引用本文： | 王秋娟, 张陆勇, 唐明月, 后德辉, 刘静涵. 盐酸关附甲素注射液对实验性心律失常的作用[J]. 中国现代应用药学, 1996, (4): 7-9. |
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| 作者姓名： | 王秋娟 张陆勇 唐明月 后德辉 刘静涵 |
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| 作者单位： | 中国药科大学 |
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| 摘 要： | 关附甲素是从关白附子块根中提取的一种新生物碱。实验表明ＩＧＦＡＨ（５０ ｇ／ｍｌ）对大鼠离体心脏结扎冠脉诱发的室性心律失常有明显的保护作用，ＩＧＦＡＨ３、６、１２ｍｇ／ｋｇｉｖ能显著提高电刺激麻醉兔心室致颤阈值，ＩＧＰＡＨ１３．４，１６．８，２１．０ｍｇ／ｋｇｉｖ能明显对抗Ｃａｌ２－Ａｃｈ液诱发小鼠房扑（颤），其ＥＤ５０为１２．４±１．５ｍｇ／ｋｇ。ＩＧＦＡＨ１０，２５，４０ｍｇ／ｋｇｉｖ对乌头碱诱发的大鼠室性心律失常有明显的保护作用。ＩＧＦＡＨ小鼠ｉｖ的ＬＤ５０为１６３．９ｍｇ／ｋｇ，其９６％可信限为１５１．９—１７６．７ｍｇ／ｋｇ。
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| 关 键 词： | 盐酸关附甲素注射液 抗心律失常作用 室性心律失常 致室颤阈 乌头碱 房扑(颤) |
The Effect of Injection Guan Fu Base A Hydrochloride (IGFAH) onExperimental Cardial Arrhythmias |
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| Wang Qiu-juan, Zhang Lu-yong et al, . The Effect of Injection Guan Fu Base A Hydrochloride (IGFAH) onExperimental Cardial Arrhythmias[J]. Chinese Journal of Modern Applied Pharmacy, 1996, (4): 7-9. |
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| Authors: | Wang Qiu-juan Zhang Lu-yong et al. |
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| Abstract: | Guan-fu base A is a new alkaloid isolated from the root ef Aconitum Coreanum.Results showed that IGFAH (50ug/ml ) had obviously protective effect against the ventriculararrhythmia caused by ligation of coronory artery in isolated hearts of rats. The ventriculai fibrillation threshold to electrical stimulation was markedly elevated in anesthetized rabbits by givenIGFAH (3,6, 12 mg/kg iv). IGFAH (13.4, 16.8, 21 .0 mg/kg iv) could antagonize atrial flutter(fibrillation) induced by CaCl2-Ach in mice markedly With ED50 of 12 .4 1 .5 mg/kg.An intravenous dose 10,25,40 mg/kg of IGFAH had significant protective reffect against the aconitineinduced ventricular anhythmia in rats. |
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| Keywords: | Injection Guan fu Baase A Hydrochloride (IGFAll ) antiarrhythmic activity ventricalar arrhythmia ventricular fibrillation threshold aconitine atrial flutter (Jibrillation ) |
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