High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis

Authors:	Maria Papp Nora Sipeki Zsuzsanna Vitalis Tamas Tornai Istvan Altorjay Istvan Tornai Miklos Udvardy Kai Fechner Silvia Jacobsen Bianca Teegen Andrea Sumegi Gabor Veres Peter Laszlo Lakatos Janos Kappelmayer Peter Antal-Szalmas

Affiliation:	¹ 2nd Department of Medicine, Division of Gastroenterology, University of Debrecen, Debrecen, Hungary;² 2nd Department of Medicine, Division of Hematology, University of Debrecen, Debrecen, Hungary;³ EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany;⁴ Vascular Biology, Thrombosis and Hemostasis Research Group, Hungarian Academy of Sciences, Debrecen, Hungary;⁵ 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary;⁶ 1st Department of Medicine, Semmelweis University, Budapest, Hungary;⁷ Department of Laboratory Medicine, University of Debrecen, Debrecen, Hungary

Abstract:

Keywords:	ANCA, anti-neutrophil cytoplasmic antibody IIF, indirect immunofluorescence C-ANCA, cytoplasmic anti-neutrophil cytoplasmic antibody P-ANCA, perinuclear anti-neutrophil cytoplasmic antibody PR-3, proteinase-3 MPO, myeloperoxidase TBB-5, human β tubulin isotype-5 BT, bacterial translocation MELD, model for end-stage liver disease SBP, spontaneous bacterial peritonitis PPI, proton pump inhibitor chronic HCV, chronic hepatitis C virus CSI, clinically significant bacterial infection CRP, high-sensitivity C reactive protein PCT, procalcitonin PMN, polymorphonuclear cell PBC, primary biliary cirrhosis AMA, antimitochondrial antibodies sIgA, secretory IgA SC, secretory component ELISA, enzyme-linked immunosorbent assay ASCA, anti-Saccharomyces cerevisiae antibodies OMP, outer membrane protein SD, standard deviation IQR, interquartile range ANOVA, one-way analysis of variance OR, odds ratio HR, hazard ratio 95% CI, 95% confidence intervals CLD, chronic liver diseases BAFF, B cell activating factor APRIL, a proliferation-inducing ligand TGF, transforming growth factor IL, interleukin TLR, toll-like receptor TNFα, tumor necrosis factor alpha iNOS, inducible nitric oxide synthase sCD89, soluble CD89 mIgA, monomeric immunoglobulin A pIgA, polymeric immunoglobulin A LBP, serum lipopolysaccharide-binding protein anti-PPS, anti-pneumococcal polysaccharide antibody
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