Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice |
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| Authors: | Kunal Chaudhary Christian LiedtkeSvenja Wertenbruch Christian TrautweinKonrad L. Streetz |
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| Affiliation: | Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany |
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| Abstract: | |
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| Keywords: | Casp, Caspase Casp8Δhepa, Casp8 knockout mice Casp8ΔMx, ubiquitous deletion of Casp8 Casp8loxP/loxP, Casp8 knockout allele DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine LPC, liver progenitor cell Mx1, myxovirus resistance-1 WT, wild type i.p., intraperitoneally pIpC, polyriboinosinic-polyribocytidylic 4 wk, 4 weeks NPCs, non-parenchymal cells TUNEL, terminal deoxynucleotidyltransferase-mediated nick end labelling BrdU, 5-bromo-2-deoxyuridine RT, real-time PCR, polymerase chain reaction ALT, alanine-aminotransferase BMT, bone marrow transplantation BM, bone marrow SD, standard deviation wt, weight |
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