Severe immune-mediated drug-induced liver injury linked to ibandronate: A case report |
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| Authors: | Nicolas Goossens Laurent Spahr Laura Rubbia-Brandt |
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| Affiliation: | 1 Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland;2 Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland |
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| Abstract: | Ibandronate is a widely used bisphosphonate with no previously well documented hepatotoxicity. We report the first case of ibandronate-related hepatotoxicity and, to our knowledge, the first case of immune-mediated drug-induced liver injury (DILI) related to bisphosphonates. |
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| Keywords: | AST, aspartate aminotransferase ALT, alanine aminotransferase CT, computed tomography HIV, human immunodeficiency virus N, normal DILI, drug-induced liver injury AIH, auto-immune hepatitis ULN, upper limit of normal RUCAM, Roussel Uclaf Causality Assessment Method LFTs, liver function tests |
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