肺癌全肺切除655例临床分析

目的探讨全肺切除术在中晚期肺癌治疗中的作用。方法对1994年10月—2003年11月行全肺切除术的655例肺癌病例进行回顾性分析。结果全组1、3、5年生存率为88.0%、50.9%、24.1%。按照TNM分期5年生存率:Ⅰa期37.0%,Ⅰb期40.6%,Ⅱa期0%,Ⅱb期37.9%,Ⅲa期19.3%,Ⅲb期7.0%,Ⅳ期17.7%。不同病理类型5年生存率:非小细胞癌24.5%,小细胞癌22.0%。术后死亡率和并发症率分别为2.4%和10.4%。结论全肺切除术有可接受的术后死亡率和并发症率,在严格掌握手术适应症的基础上,术中操作熟练规范,重视围手术期的观察和处理,全肺切除术对于治疗中、晚期肺癌仍不失为一种有效的方法。

Clinical analysis of pneumonectomy in 655 patients with lung cancer

Objective To investigate the role of pneumonectomy in the treatment on patients with lung cancer.Methods We reviewed 655 consecutive patients with lung cancer treated with pneumonectomy between October 1994 and November 2003.Results The survival rates for 1,3,5 years in these patients were 88.02%,50.09% and 24.1%,respectively.The 5-year survival rates for different pTNM stage of cases were as follows: stage Ⅰa 37.0%,Ⅰb 40.6%,Ⅱa 0%,Ⅱb 37.9%,Ⅲa 19.3%,Ⅲb 7.0%,Ⅳ17.7%.The 5-year survival rate for NSCLC was 24.5%,and that for SCLC was 22.0%.The postoperative mortality and complication were 2.4% and 10.4%,respectively.Conclusion On the basis of strict indication and practiced thoracic operation,the pneumonectomy showed acceptable postoperative complication and mortality,it would be a effective method in treatment on middle and advanced stage of lung cancer.