Relationship between serum copper and protein thiols in hyperlipidemic patients |
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| Authors: | Jeevan K Shetty Suresh Babu Sudeshna Tripathy Mungli Prakash |
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| Institution: | [1]Department of Biochemistry,Kasturba Medical College,Manipal University,Karnataka,India [2]Deartment of Biochemistry,JJM Medical College,Davanagere,Karnataka,India [3]Indian institute of Science Bangalore,Karnataka,India [4]Department of Biochemistry and Genetics,St.Mathews University,School of Medicine,Grand Cayman,Cayman Island,BWI. |
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| Abstract: | Objective:To measure serum copper and protein thiols along with lipid profile in hyperlipidemic patients and to establish the relationship between serum copper,protein thiols and lipid profile parameters.Methods: The study group consisted of 26 newly diagnosed hyperlipidemic patients not associated with any other systemic diseases and 26 age and sex matched healthy controls.Fasting lipid profile was done by enzymatic method using automated analyzer.Serum copper and protein thiols were measured spectrophotometrically.Results: Serum copper and protein-SH levels were significantly decreased in cases(P<0.01,P<0.01)compared to controls.Serum copper correlated positively with protein thiols(r=0.800,P<0.01)and negatively with LDL cholesterol(r=-0.351 P<0.05).Conclusion: Serum copper and protein thiols were decreased in hyperlipidemia and they correlated positively indicating protective role of copper in preventing homocysteinylation of protein and hence in preventing atherosclerosis. |
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| Keywords: | Hyperlipidemia Serum Copper Protein thiols Low density lipoprotein |
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