中风病急性期甲状腺激素变化与中医证候的相关性研究

目的探讨中风病急性期血清甲状腺激素的检验结果与中医证候的相关性。方法运用统计学中相关性分析的方法研究中风病发病72h和14d两时点甲状腺激素水平与中医证候要素评分及美国国立卫生研究院卒中量表（NIHSS）评分的相关性。结果发病72h内三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）及超敏促甲状腺素（TSH）的检测值均与火热证评分及NIHSS评分具有相关性;T3值与阴虚阳亢证评分、游离甲状腺素（FT4）值与血瘀证评分分别具有相关性;T3值及FT3值与年龄具有相关性。发病14d时T3、T4、FT3的值皆与血瘀证评分具有相关性;FT3值与痰证评分及NIHSS评分具有相关性;T4值与年龄具有相关性。结论在中风病72h内甲状腺激素水平与火热证评分及NIHSS评分呈负相关,在发病14d时甲状腺激素水平与血瘀证评分呈负相关;两个时点的甲状腺激素水平均与年龄有不同程度的相关性。

Correlation between thyroid hormones and TCM symptoms in acute seizure phase of stroke

Objective To investigate the correlation between the test results of serum thyroid hormones and TCM symptoms in the patients with stroke in the acute seizure phase. Methods The statistical method of correlation analysis and Stroke Scale of National Institute of Health of America (NIHSS) were used to study the levels of thyroid hormones and factor scores of TCM symptoms at two time points (72 hours and 14 days after the attack of stroke). Results At 72 hours after the attack of stroke the detective values of thyroid hormones [triiodothyronine (T3), thyroxin (T4), free triiodothyronine (FT3) and thyrotrophic supersensitivity hormone (TSH)] were correlated negatively to the scores of fire-heat syndrome and NIHSS. The values of T3 and FT4 had negative correlations respectively to the scores of the syndrome of yin deficiency with yang hyperactivity and blood stasis syndrome. The values of T3 and FT3 were correlated to age. At 14 days after the attack of stroke all values of T3, T4 and FT3 were correlated negatively to the scores of blood stasis syndrome, the value of FT3 had a negative correlation to the scores of phlegm syndrome and NIHSS, and the value of T4 was correlated to age. Conclusion The serum levels of thyroid hormones are negatively correlated to the scores of fire-heat syndrome and NIHSS within 72 hours of the attack of stroke, and are correlated negatively to the score of blood stasis syndrome 14 days after the attack of stroke. The serum levels of thyroid hormones are correlated to age, to different extents, at two time points.