| 膜骨架连接蛋白Ezrin对肺癌细胞侵袭和转移能力的影响 |
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| 引用本文： | 高辉,李庆昌.膜骨架连接蛋白Ezrin对肺癌细胞侵袭和转移能力的影响[J].解剖科学进展,2011,17(6):575-581. |
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| 作者姓名： | 高辉 李庆昌 |
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| 作者单位： | 中国医科大学基础医学院病理学教研室,辽宁沈阳,110001 |
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| 基金项目： | 国家自然科学基金资助项目(No.30700806) |
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| 摘 要： | 目的 探讨肺癌细胞中膜骨架连接蛋白Ezrin对体外培养的肺癌细胞系的增殖、凋亡、侵袭和转移能力的影响,明确Ezrin在肺癌中的异常表达与临床病理因素之间的关系.方法转染Ezrin SiRNA后,应用流式、MTT、Transwell和划痕实验等技术评价肺癌细胞体外侵袭转移和增殖能力的变化.结果转染Ezrin SiRNA ...
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| 关 键 词： | Ezrin 连接蛋白 肺癌 侵袭转移 |
Membrane-cytoskeleton linking protein Ezrin enhances invasion and metastasis of lung cancer cells |
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| GAO Hui,LI Qing-chang.Membrane-cytoskeleton linking protein Ezrin enhances invasion and metastasis of lung cancer cells[J].Progress of Anatomical Sciences,2011,17(6):575-581. |
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| Authors: | GAO Hui LI Qing-chang |
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| Institution: | GAO Hui,LI Qing-chang*(Department of Pathology,College of Basic Medical Sciences,China Medical University,Shenyang 110001 China) |
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| Abstract: | Objective To research the influence of Membrane-cytoskeleton linking protein Ezrin on apoptosis,invasiveness and metastasis of lung cancer cells in vitro and to find out the relationship between the clinicopathological factors and the overexpresion of Ezrin in lung cancer.Methods After Ezrin SiRNA transfection,the invasion,metastasis and proliferation changes of lung cancer cells in vitro were evaluated by Flow cytometry,MTT,Transwell,wound healing assay.Results After Ezrin SiRNA transfection,invasion and p... |
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| Keywords: | Ezrin linking protein lung cancer metastasis |
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