| Effects of morphine and electroacupuncture on substance P level in spinal cord and their relation to pain threshold in rats |
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| 引用本文： | 阮怀珍,李希成,黎海蒂. Effects of morphine and electroacupuncture on substance P level in spinal cord and their relation to pain threshold in rats[J]. 中国人民解放军军医大学学报, 1993, 0(1) |
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| 作者姓名： | 阮怀珍 李希成 黎海蒂 |
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| 作者单位： | Department of Physiology Third Military Medical College Chongqing 630038，Department of Physiology，Third Military Medical College Chongqing 630038，Department of Physiology，Third Military Medical College Chongqing 630038 |
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| 摘 要： | Immunoreactive substance P(Ir-SP)level,and substance P likeimmunoreactivity(SP-Li)in the spinal cord were observed with radioimmunoassay andimmunohistochemistry in rats after they were given an intraperitoneal injection of mor-phine(7.5mg/kg)or electroacupunctured(3V and 3Hz)on the “Jiaji point”.It wasfound that the pain threshold(PT),Ir-SP level and SP-Li in the dorsal horn of the spi-nal cord were more significantly increased in the animals after the administration ofmorphine or electroacupuncture than in the control(P<0.05～0.01).The combined effectsof morphine and electropacupuncture were even more powerful than either of the agentswas administered singly.Naloxone could block the analgesic effect and the elevation ofIr-SP due to morphine or electroacupuncture.The findings suggest that there is a synergismbe tween morphine and electroacupuncture and the analgesic effect of the 2 depends uponthe increase of Ir-SP level of the spinal cord mediated through the opiate receptors.
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Effects of morphine and electroacupuncture on substance P level in spinal cord and their relation to pain threshold in rats |
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| Ruan Huaizhen Li Xicheng Li Haidi. Effects of morphine and electroacupuncture on substance P level in spinal cord and their relation to pain threshold in rats[J]. Journal of Medical Colleges of PLA(China), 1993, 0(1) |
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| Authors: | Ruan Huaizhen Li Xicheng Li Haidi |
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| Affiliation: | Ruan Huaizhen Li Xicheng Li Haidi Department of Physiology,Third Military Medical College,Chongqing 630038 |
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| Abstract: | |
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| Keywords: | morphine electroacupuncture spinal cord substance P radioimmunoassay immunohistochemistry pain threshold animal rats |
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