| 慢性粒细胞性白血病bcr/abl融合基因的表达 |
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| 引用本文： | 吴昌学,曾小箐,单可人,李毅. 慢性粒细胞性白血病bcr/abl融合基因的表达[J]. 贵阳医学院学报, 2003, 28(4): 320-322 |
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| 作者姓名： | 吴昌学 曾小箐 单可人 李毅 |
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| 作者单位： | 1. 贵阳医学院,分子生物学重点实验室,贵州,贵阳,550004
2. 贵阳医学院附院,血液内科,贵州,贵阳,550004 |
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| 摘 要： | 目的：研究慢性粒细胞性白血病患者bcr／abl融合基因阳性率及其临床意义。方法：取慢性粒细胞性白血病(CML)患者骨髓或外周血，提取单核细胞的总RNA，用逆转录多聚酶链反应(RT-PCR)，观察其ber／abl基因的表达。结果：9例CML患者中，8例ber／abl基因阳性，占88.9％。结论：bcr／abl基因检测可以用来辅助CML的临床诊断。
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| 关 键 词： | 慢性粒细胞性白血病 bcr／abl 融合基因 表达 逆转录聚合酶链反应 |
| 文章编号： | 1000-2707(2003)04-0320-03 |
| 修稿时间： | 2003-02-26 |
Expression of Bcr/abl Fusion Gene in Chronic Myelogenous Leukemia |
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| WU Chang-xue,ZENG Xiao-qing,SHAN Ke-ren,LI Yi. Expression of Bcr/abl Fusion Gene in Chronic Myelogenous Leukemia[J]. Journal of Guiyang Medical College, 2003, 28(4): 320-322 |
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| Authors: | WU Chang-xue ZENG Xiao-qing SHAN Ke-ren LI Yi |
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| Abstract: | Objective:To investigate the positive expression rate of bcr/abl fusion gene in chronic myelogenous leukemia (CML) and its clinical significance. Methods: The RT-PCR technique was used to detect the bcr/abl gene in CML. Results: Out of 9 cases of chronic phase of CML, 8 showed positive expression of bcr/abl gene which accounted for 88. 9% . Conclusions: Bcr/abl gene detecting technique has significance in clinical classification of CML. When bcr/abl gene expresses positively, it contributes to differential diagnosis in blast crisis of CML and acute myelogenous leukemia ( AML) at the first diagnosis. |
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