影响不明原因不孕患者IVF受精率的因素分析

目的探讨不明原因不孕患者首次IVF治疗影响其受精率的因素。方法将44个首次行IVF方案的不明原因不孕患者的,根据受精率高低划分为受精率高组（A组28例,受精率〉50%）和受精率低组（B组16例,受精率≤50%）,比较2组之间年龄、不孕年限、促排卵方案、成熟卵母细胞数、优质胚胎数、妊娠率及种植率有无差异。结果 44例患者在年龄、基础FSH、启动Gn数、用药时间、总Gn用量、获得卵细胞均无明显统计学差异,但A组不孕时间短于B组,且获得成熟卵母细胞的比率较B组高,获得的优质胚胎率也显著高于B组,有统计学差异（P=0.002,P〈0.05）;A组临床妊娠率为32%,高于B组的14.28%。结论不明原因不孕患者行首次IVF治疗时,应综合分析年龄、不孕时间及获卵数来判断受精方式,不要盲目扩大ICSI指征。

Factors analysis of fertilization rate for couples with unexplained infertility undergoing in vitro fertilization

Objective：To analyze the factors of fertilization rate for couples with unexplained infertility undergoing first in vitro fertilization （ivf）.Methods：According to the fertilization rate,44 patients undergoing first IVF were divided into two groups：high fertilization group （fertilization rate 50%）,group A （n=28） and low fertilization group （≤50%）,group B （n=16） ;Using of statistics to analysis age,infertility years,the superovulation programs,number of MII oocytes,good-quality embryos,pregnancy rate and implantation rate between two ggroups.Results：There was no statistically significant difference with age,baseline FSH,days of stimulation,total gonadotrophin amount,number of CCOCs retrieved between group A and group B,however infertility years of group A were shorter than those of group B,the rate of M II oocytes and good-quality embryos were higher than those of group B.There was obviously statistical difference between the two groups （P=0.002,P 0.05）.The pregnancy rate of group A （32%） was higher than that of group B （14.28%）.Conclusions：The way of fertilization for couples with unexplained infertility undergoing first ivf should be choosed by age,infertilyty years and the Number of CCOCs retrieved.It was not claimed that ICSI indication would be blindly expanded.