孕前半年父亲铅暴露与子代先天性心脏病病因的关联

目的探讨孕前半年父亲环境危险因素暴露与子代先天性心脏病的病因学关联,为CHD的预防提供依据。方法采用统一制定的调查表,按1:2进行匹配,对先心病例组和对照组的父母分别进行面对面结构式访谈,调查相关的影响因素。结果孕前半年父亲铅暴露(OR=4.516)、母亲自然流产史(OR=5.656)、孕前和孕早期夫妻经常争吵(OR=3.557)与子代CHD的发生存在显著相关性(P0.05)。结论父亲的职业环境和母亲的精神因素应给予高度关注,积极寻找自然流产史夫妇的高危因素,对预防子代CHD的发生尤为重要。

Relationship between the congenital heart disease and the fathers exposure to environmental risk factors six months before pregnancy.

Objective： To determine the relationship between the congenital heart disease and the fathers exposure to environmen- tal risk factors six months before pregnancy, and to provide basis for the prevention of CHD. Methods ： A 1 ： 2 case - control study was designed and face - to - face structured interviews was took in parents both the case of CHD and control group to investigate the impact of related factors. Results： Fathers lead exposure six months before pregnancy （OR = 4. 516） , mothers＇ history of spontaneous abortion （OR = 5. 656） , parents＇ quarrel prepregnancy and early pregnancy （OR = 3. 557 ） were influencing the occurrence of CHD, with P values less than 0. 05. Conclusion： Paying great attention to occupational factors of fathers and the spirit factors of mothers, looking for high - risk factors of couples with history of spontaneous abortion actively will be particularly important for the prevention of CHD offspring.