口服避孕药预治疗对多囊卵巢综合征患者体外受精-胚胎移植结果的影响

目的探讨多囊卵巢综合征(PCOS)患者应用口服避孕药预治疗对体外受精-胚胎移植(IVF-ET)结局的影响。方法 192例PCOS患者IVF-ET周期随机分成两组:研究组IVF-ET前先用口服避孕药(妈富隆或达英35)预治疗93例,对照组99例。比较两组年龄、促性腺激素(Gn)用量、获卵数、受精率、植入率、妊娠率、流产率和卵巢过度刺激综合征(OHSS)的发生率。结果两组年龄、Gn用量、获卵数、受精率无明显差异,预治疗组的植入率、妊娠率显著高于对照组(P0.05)。流产率和卵巢过度刺激综合征(OHSS)的发生率对照组(9.1%)显著高于研究组(5.2%)。结论 PCOS患者IVF-ET前先用口服避孕药顸治疗可提高植入率和妊娠率,降低OHSS的发生率。

Effect of desogestrel - ethinylestradiol on the result of in vitro fertilization and embryo transfer of patients with polycystic ovary syndrome.

Objective ： To study the effect of beforehand treatment with oral contraception （OC） on patients with polycystic ovary syndrome （PCOS） before in vitro fertilization and embryo transfer （IVF -ET）. Methods： 192 patients suffered from PCOS receiving IVF - ET were divided into two groups ： 93 cases taken oral contraception （ Marvlon or Dain 35 ） as beforehand treatment before IVF - ET, the other 99 eases without OC were taken as control group. The patients＇ age, number of oocyte retrieving, fertilization rate, implantation rate, and pregnancy rate and ovarain hyperstimulation syndrom （OHSS） were compared. Results： The age, number of Gn using and oocyte, fertilization rate had no difference （ P 〉 0.05 ） between two groups. But the implantation rate and pregnancy rate in beforehand treatment group were significantly higher than those in control group （ P 〈 0. 05）. The abortion rate and occurrence rate of OHSS in study group （9. 1% ） were less than that in control group （5.2%）. Conclusions： Beforehand treatment with OC to PCOS patients before IVF - ET could increase the implantation and pregnancy rates and reduce the occurrence rate of OHSS .