85例早期自然流产绒毛染色体核型分析

目的对85例自然流产绒毛标本染色体核型进行分析,探讨早期流产的原因。方法取流产绒毛细胞进行原位培养,G显带,染色体核型分析。培养失败标本以荧光原位杂交协助诊断。结果 85例早期流产患者绒毛标本染色体异常共28例,占32.94%,检出的染色体异常类型有：常染色体三体10例（35.71%）,性染色体异常7例（25.00%）,嵌合体2例（7.14%）,三倍体6例（21.42%）,四倍体1例（3.57%）,双重三体1例（3.57%）,结构异常1例（3.57%）。结论胎儿染色体异常是早期自然流产的重要原因,绒毛染色体检测为临床咨询提供重要的理论依据。

Chromosome karyotype analysis of chorionic villus in 85 cases early spontaneous abortion

Objectives：85 cases chorionic villus samples from the patients with spontaneous abortion were collected for chromosome karyotype analysis to study the cause of early spontaneous abortion.Methods：The chorionic villus cells were used in situ cultivation,G banding,and chromosome karyotype analysis.The samples cultivated unsuccessfully were assisting diagnosed with fluorescence in situ hybridization.Results：Of 85 cases chorionic villus samples from the patients with early spontaneous abortion,28 cases were chromosomal abnormalities （32.94%）,the karyotype of chromosomal abnormalities as follow：10 cases were antosomal triploids （35.71%）,7 cases were sexual chromosome abnormalities （25.00%）,2 cases were mosaics （7.14%）,6 cases were trpolids （21.42%）,1 case was tetraploids （3.57%）,1 case was double triploids （3.57%）,and 1 case was structural aberrations （3.57%）.Conclusions：Chromosomal abnormalities are important factors of early spontaneous abortion,analysis of chorionic villus chromosome provides an important theoretical basis for clinical consultation.