新生儿窒息后心肌酶检测的临床价值探讨

目的探讨心肌酶在新生儿窒息后引起的缺氧性心肌损伤中的变化及临床价值。方法选择新生儿科86例窒息新生儿,按窒息程度分为轻度窒息、重度窒息两组,于24h内及治疗七天后抽血检测天冬氨酸氨基移换酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶同工酶MB（CK-MB）、α-羟丁酸脱氢酶（α-HBDH）,并选择同期出生的正常新生儿30例作为对照组进行分析比较。结果新生儿轻、重度窒息组血清AST、LDH、CK、CK-MB、HBDH明显高于对照组,而重度窒息组又明显高于轻度窒息组,经统计学处理有非常显著意义（P〈0.01）。结论新生儿窒息早期即有心肌酶活性升高,升高水平与新生儿窒息程度呈正相关;心肌酶谱检测可作为新生儿窒息后提示心肌损害的早期、灵敏的重要指标,临床上有重要实用价值。

Exploring the clinical value of myocardial enzyme detection in asphyxia newborn

Objective：To explore the change of myocardial enzyme with the anoxia myocardial injury and its clinical value in asphyxia newborn.Methods：86 asphyxia newborns hospitallized in newborn department,were classified into mild asphyxia group and severe asphyxia group by the degree of asphyxia.The level of AST,LDH,CK,CK-MB,HBDH in the venons sample were detected and analized,which of the 86 cases were got through at 24 hours after birth and 7 days after therapy.30 normal newborns without anoxia constituded the control group,the result were analized.Resluts：The mean serum values of AST,LDH,CK,CK-MB,HBDH in mild and severe ashpyxia group rose obviously and had significant defference compared to control group（P〈0.01）.And those in severe ashpyxia group also had significant defferenc to mild ashpyxia group（P〈0.01）.Conclusion：The level of myocardial enzyme rise rapidly early after neonatal asphyxia,and is correlative positively with the degree of asphyxia;The myocardial enzyme detection has important clinical value,for may be used as the early and sensitive mark to discover myocardial injury after neonatal asphyxia.