瘦素与多囊卵巢综合征的相关分析

目的探讨血清中瘦素（Leptin）水平与多囊卵巢综合征（PCOS）的关系。方法采用免疫化学发光法检测68例PCOS患者和32例正常妇女血清中的廋素、性激素水平,同时进行糖耐量及胰岛素释放试验。结果 PCOS组血清瘦素水平明显高于对照组（P〈0.05）;PCOS组与对照组相比,除E2水平无显著性差异（P〈0.05）外,其余各项LH、T、PRL、FSH、A4差异显著（P〈0.05）;PCOS组中非肥胖与肥胖组间,除了T、A4差异显著（P〈0.05）外,其余指标差异均无统计学意义（P〈0.05）;PCOS组中瘦素与FINS（r=0.726,P〈0.01）、IR（r=0.631,P〈0.01）、AUC（r=0.518,P〈0.01）、ISI（r=0.663,P〈0.05）均呈正相关关系。结论瘦素可能参与PCOS的发生、发展,并与胰岛素抵抗、高胰岛素血症密切相关。

Study on the relationship between serum Leptin leve and polycystic ovary syndrome

Objective：To study the relationship of serum Leptin level and PCOS patients.Methods：Serum Leptin and sex hormone were determined in 68 patients with PCOS and 32 contrary subjects,and simultaneously do carbohydrate tolerance test and insulin releasing test.Results：The value of serum Leptin level in PCOS group were much higher than those in the contrary group（P0.05）;The value of serum LH,T,PRL,FSH,A4 in PCOS group were obviously different from those in the contrary group（P0.05）,in contrast,serum E2 show unclear distinction（P0.05）.The value of T and A4 are much diverse from fat group and the contrary group in PCOS（P0.05）,the rest have no statistical significance.There are positive correlation between Leptin and FINS（r=0.726,P0.01）,IR（r=0.631,P0.01）,AUC（r=0.518,P0.01）,ISI（r=0.663,P0.05）.Conclusion：Leptin may participate occurrence and development of PCOS,there is a close relationship between insulin resistance and Hyperinsulinemia.