可溶性CD105在早发型子痫前期患者中的表达

目的探讨早发型子痫前期患者可溶性CD105（sCD105）表达的变化和意义。方法选择对照组和早发型子痫前期组各30例,其中32周之前发病患者13例,32周之后发病患者17例;选择在本院行产前筛查后发展为早发型子痫前期的妊娠妇女和对照组各30例。采用酶联免疫吸附分析法（ELISA）测定各组血清sCD105水平。结果对照组和早发型子痫前期组血清sCD105水平的中位数分别为13.45ng/ml和36.35ng/ml,差异有统计学意义（P=0.000）。32周之前发病组和32周之后发病组血清sCD105水平的中位数分别为48.76ng/ml和30.39ng/ml,差异有统计学意义（P=0.02）。对照组和早发型子痫前期组妊娠中期sCD105水平的中位数分别为5.20ng/ml和7.51ng/ml,差异有统计学意义（P=0.003）。32周之前发病组和32周之后发病组妊娠中期血清sCD105水平的中位数分别为8.43ng/ml和5.41ng/ml,差异有统计学意义（P=0.011）。结沦早发型子痫前期患者血清sCD105水平显著增高,发生早发型子痫前期的妊娠中期孕妇的sCD105也显著增高,发病孕周越早血清sCD105水平上升更显著。

The explession of soluble endoglin in early-onset preeclampsia

Objective：To explore the explession of soluble endoglin in early onset preeclampsia.Methods：In the current investigation,30 women with early onset preeclampsia and 30 normal pregnant women were recruited,among whom were 13 before 32 weeks and 17 after 32 weeks.30 pregnant women who attended Down＇s syndrome screening test at the gestational of 15-20 weeks and subsequently developed early onset preeclampsia and 30 normal pregnant women were recruited.The concentrations of soluble endoglin in serum were determined by enzyme-linked immunosorbent assay （ELISA）.Results：Serum level of soluble endoglin was significantly higher in early onset preeclampsia group than in control （median：36.35 ng /ml versus 13.45 ng /ml,P=0.000）.When preeclamptic women were stratified into before 32w and after 32w,those before 32w had significantly higher serum endoglin than those after 32w （median：48.76 ng/ml versus 30.39 ng/ml,P=0.02）.At early second trimester （15-20 weeks of gestation）,serum level of endoglin was significantly higher in women who subsequently developed preeclampsia than the women who had good prognosis （median：7.51ng /ml versus 5.20 ng /ml,P=0.003）.The early onset preeclamptic women before 32w had significantly higher serum endoglin than those after 32w （median：8.43 ng /ml versus 5.41 ng /ml,P=0.011）.Conclusion：Soluble endoglin was increased in early onset preeclamptic women and this increase occurred in the second trimester of preeclampsia-complicated pregnancy and more significantly in earlier onset genstation.