1387例男性不育患者染色体核型及临床分析

目的对1387例男性不育患者染色体核型及临床表现进行分析,探讨男性染色体畸变与表型的效应关系,分析男性不育患者染色体异常检出率及异常类型和频率分布。方法外周血淋巴细胞培养,常规染色体G显带分析。结果 1387例男性不育患者中染色体异常249例,其中常染色体结构异常127例,占51.00%;性染色体数目异常28例,占11.24%;性染色体结构异常94例,占37.76%。249例男性染色体异常患者中无精子症43例,占17.27%,少精子症39例,占15.66%;配偶反复自然流产、胎停育124例,占49.80%,配偶有畸形儿分娩史39例,占15.66%,患者智力低下、发育异常4例,占1.61%。249例男性染色体异常涉及1、2、3、4、5、6、7、9、10、13、14、15、18、21、22和Y等染色体。结论染色体畸变是导致男性不育的重要因素,对久治不愈的男性不育患者应检查染色体以排除染色体畸变的可能。

Clinical Investigation and Chromosomal Analysis of 1387 Cases of Male Patients with Infertility.

Objective： The objective was to investigate and analyze the relationship between chromosome abnormalities and the phenotype effect of 1387 male patients with infertility.Methods： Peripheral blood lymphocyte culture and conventional chromosome analysis by G-band was conducted.Results： In 249 cases of male patients with chromosome abnormalities,the case numbers of euchromosome abnormalities were 127 and accounted for 51.00%.The number of sex chromosome abnormalities and sex chromosome structure abnormalities were 28 and 94,respectively,and accounted for 11.24% and 37.76%,respectively.Among these cases patients with azoospermia and oligospermia were 17.27% and 15.66% respectively.To their spouses,repeatedly spontaneous abortion,fetal death accounted for 49.80%,terata accounted for 15.66%,and sexual organs abnormality accounted for 1.61%.Chromosome abnormalities were comprised of the 1st,2nd,3rd,4th,5th,6th,7th,9th,10th,13th,14th,15th,18th,21st,22nd and Y chromosome among 249 cases.Conclusion： Chromosome aberrance played an important role in male infertility.Chromosome examination should be performed to exclude the possibility of chromosome aberrances in patients with obstinate infertility.