| 羟乙基淀粉对患者凝血功能影响的临床研究 |
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| 引用本文： | 夏磊铭,袁世荧,姚尚龙,卫富强.羟乙基淀粉对患者凝血功能影响的临床研究[J].华中科技大学学报(医学版),2002,31(1):99-100. |
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| 作者姓名： | 夏磊铭 袁世荧 姚尚龙 卫富强 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院麻醉科,武汉，430022 |
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| 摘 要： | 为研究羟乙基淀粉对凝血功能的影响，将20例颅脑外科患者采取随机双盲法分成两组，一组输注10％羟乙基淀粉溶液。另一组输注6％羟乙基淀粉溶液，在同等条件下，比较输注羟乙基淀粉溶液前、后凝血功能的改变。结果显示：输注6％羟乙基淀粉溶液500ml后白陶土部分凝血活酶时间（APTT）、纤维蛋白原、凝血酶原时间（PT）与输注前相比无显著差异。输注10％羟乙基淀粉溶液500ml后，APTT、纤维蛋白原含量与输注前相比无显著差异，但PT值明显大于输注前（P＜0．05）。提示：输注6％羟乙基淀粉溶液后对凝血功能无改变;输注10％羟乙基淀粉溶液后病人PT时间延长，但临床观察无出血倾向。
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| 关 键 词： | 羟乙基淀粉 凝血功能 休克 低血容量 |
Clinical Research of the Influence of Hydroxyethyl Starch Sol ution on Coagulation |
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| Xia Leiming,Yuan Shiying,Yao Shanglong et al.Clinical Research of the Influence of Hydroxyethyl Starch Sol ution on Coagulation[J].Journal of Huazhong University of Science and Technology(Health Sciences),2002,31(1):99-100. |
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| Authors: | Xia Leiming Yuan Shiying Yao Shanglong |
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| Institution: | Xia Leiming,Yuan Shiying,Yao Shanglong et al Department of Anesthesiology,Xiehe Hospital,Tongji Medical College. Huazhong University of Science and Technology,Wuhan 430022 |
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| Abstract: | To observe the influence of hydroxyethyl starch solution on coagulation, 20 patients were investigated. The patients were divided into two groups: group one, 10 % hydroxyethyl starch solution group (n=10) and group two, 6 % hydroxyethyl starch solution group (n=10). The alterlations of coagulation pro-infusion and post-infusion of hydroxyethyl starch solution were compared. The results showed that no significant change was found in the 6 % hydroxyethyl starch solution group, while the prothrombin time was significantly prolonged in the 10 % hydroxyethyl starch solution group (P<0.05), but no clinical hemorrhagic signs appeared. It was suggested that transfusion of 6 % hydroxyethyl starch solution had no influence on the coagulation, while transfusion of 10 % hydroxyethyl starch solution could prolong the prothrombin time. |
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| Keywords: | hydroxyethyl starch solution coagulation |
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