抑脂技术和动态增强MRI在胰岛素瘤诊断中的价值探讨

目的 探讨抑脂技术和动态增强MRI在胰岛素瘤术前定位诊断中的价值。方法 12例手术病理证实的胰岛素瘤患者术前行MR检查，扫描序列包括：横断面SE T1WI，快速自旋回波(FSE)T2WI，加脂肪抑制技术的T1WI和T2WI(即T1WI FS和T2WI FS)，快速多层面扰相梯度回波(FMPSPGR)序列作动态增强扫描。结果 在常规T1WI和T2WI序列仅检出4例肿瘤，表现为T1WI稍低信号和T2WI稍高信号。在T1WI FS上7例呈均匀低信号，显示清晰；在T2WI FS上6例病灶呈不同程度的高信号。快速动态增强扫描(FMPSPGR)检出11例肿瘤，在动脉期7例肿瘤明显强化呈高信号，4例轻度强化呈稍高信号，1例无明显强化呈等信号，胰腺实质期和门脉期6例仍呈高信号，6例呈等信号。与手术后病理结果比较，动态增强MRI对胰岛素瘤术前定位诊断准确率为91．7％(11／12)。结论 动态增强MRI是胰岛素瘤术前定位诊断敏感而准确的方法。

Value of fat suppression and dynamic contrast-enhanced MRI in the diagnosis of insulinoma

Objective To evaluate the value of fat suppression and dynamic contrast-enhanced MRI in the preoperative localization of insulinoma. Methods Twelve cases with pathologically proven insulinoma were evaluated with MRI. SE T 1WI, FSE T 2WI, T 1WI and T 2WI with fat suppression, dynamic contrast-enhanced FMPSPGR sequences were used in MR scanning. Results On SE T 1WI, the lesions displayed hypointense in 4, isointense in 8 cases. Lesions showed hyperintense in 4, isointense in 8 cases on FSE T 2WI. In contrast, 7 cases appeared as hypointense on T 1WI with fat suppression and 6 cases appeared as hyperintense on T 2WI with fat suppression. With dynamic contrast-enhanced FMPSPGR sequence 11 of 12 insulinomas were detected. In the arterial phase, the lesions presented as hyperintense with different degrees in 11 cases and isointense in 1 case. 6 cases remained hyperintense and 6 cases were isointense in pancreatic parenchymal and portal phase. 4 lesions were identified only in dynamic enhancement images. The diagnostic accuracy of insulinoma by dynamic contrast-enhanced MRI was 91.7% (11/12) as compared with histological study. Conclusion The results indicate that dynamic contrast-enhanced MRI is an sensitive and accurate method for the preoperative localization of insulinoma.