Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments |
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| Authors: | Clancy Cornelius J Huang Hong Cheng Shaoji Derendorf Hartmut Nguyen M Hong |
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| Affiliation: | North Florida/South Georgia VA Medical Center, University of Florida College of Medicine, Gainesville, FL 32610, USA. clancyn@medicine.ufl.edu |
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| Abstract: | We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout. |
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