Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV |
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Authors: | Arthur Varoquaux Olivier Rager Karl-Olof Lovblad Karen Masterson Pavel Dulguerov Osman Ratib Christoph D. Becker Minerva Becker |
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Affiliation: | 1. Department of Radiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland 2. Department of Nuclear Medicine, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland 3. Department of Neuroradiology, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland 4. Department of Otorhinolaryngology Head and Neck Surgery, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
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Abstract: | Purpose Head and neck squamous cell carcinoma (HNSCC) may cause a decreased apparent diffusion coefficient (ADC) on diffusion-weighted magnetic resonance imaging (DW MRI) and an increased standardized uptake value (SUV) on fluorodeoxyglucose (FDG) positron emission tomography (PET/CT). We analysed the reproducibility of ADC and SUV measurements in HNSCC and evaluated whether these biomarkers are correlated or independent. Methods This retrospective analysis of DW MRI and FDG PET/CT data series included 34 HNSCC in 33 consecutive patients. Two experienced readers measured tumour ADC and SUV values independently. Statistical comparison and correlation with histopathology was done. Intra- and inter-observer agreement for ADC and SUV measurements was assessed. Results Intraclass correlation coefficient (ICC) analysis showed almost perfect reproducibility (>0.90) for ADCmean, ADCmin, SUVmax and SUVmean values for intra-observer and inter-observer agreement. Mean ADCmean and ADCmin in HNSCC were 1.05?±?0.34 × 10?3?mm2/s and 0.65?±?0.29 × 10?3?mm2/s, respectively. Mean SUVmean and mean SUVmax were 7.61?±?3.87 and 12.8?±?5.0, respectively. Although statistically not significant, a trend towards higher SUV and lower ADC was observed with increasing tumour dedifferentiation. Pearson’s correlation analysis showed no significant correlation between ADC and SUV measurements (r ?0.103, ?0.051; p 0.552, 0.777). Conclusion Our data suggest that ADC and SUV values are reproducible and independent biomarkers in HNSCC. |
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