| 青黛颗粒抗炎、镇痛作用的实验研究 |
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| 引用本文： | 杜立阳,刘悦,宗士群,李东安,赵金明,张艳玲. 青黛颗粒抗炎、镇痛作用的实验研究[J]. 中国医科大学学报, 2003, 32(5): 456-457,475 |
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| 作者姓名： | 杜立阳 刘悦 宗士群 李东安 赵金明 张艳玲 |
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| 作者单位： | 1. 中国医科大学附属第一医院中医科,辽宁,沈阳,110001
2. 辽宁省中医研究院药理室 |
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| 基金项目： | 辽宁省自然科学基金资助项目 (972 2 61)，沈阳市社会发展基金资助项目 (98493 40 5 13 ) |
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| 摘 要： | 目的 :通过对青黛颗粒抗炎、镇痛作用的实验研究 ,探讨该药治疗溃疡性结肠炎的作用机理。方法 :采用小鼠醋酸扭体法、大鼠棉球肉芽肿法和角叉菜胶所致大鼠足肿胀方法。结果 :青黛颗粒给药高、中、低剂量组和阳性对照药组均明显降低小鼠扭体次数 (P<0 .0 5～P<0 .0 1)。对大鼠棉球肉芽肿和大鼠足肿胀有显著的抑制作用 (P <0 .0 1～P <0 .0 0 1)。结论 :青黛颗粒分别对大鼠具有抗炎、对小鼠具有镇痛作用。且镇痛作用呈量效关系
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| 关 键 词： | 青黛颗粒 醋酸扭体法 镇痛 棉球肉芽肿 |
| 文章编号： | 0258-4646(2003)04-0456-02 |
Experimental Study on Anti-Inflammatory Effect and Analgesic Effect of Compound Qingdai Granula |
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| DU Li-yang ,LIU Yue ,ZONG Shi-qun ,LI Dong-an ,ZAO Jin-ming ,ZHANG Yan-ling. Experimental Study on Anti-Inflammatory Effect and Analgesic Effect of Compound Qingdai Granula[J]. Journal of China Medical University, 2003, 32(5): 456-457,475 |
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| Authors: | DU Li-yang LIU Yue ZONG Shi-qun LI Dong-an ZAO Jin-ming ZHANG Yan-ling |
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| Affiliation: | DU Li-yang 1,LIU Yue 1,ZONG Shi-qun 1,LI Dong-an 2,ZAO Jin-ming 2,ZHANG Yan-ling 2 |
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| Abstract: | Objective: Our aim was to study the anti-inflammatory effect and analgesic effect of compound qingdai granula (CQG) and the mechanisms. Methods:Different doses of CQG were given to mice with swelling feet induced by acetic acid, cotton balling granulation,and carrageenin. Results:The CQG could significantly inhibit swelling caused by cotton balling granulation (P< 0.01 ) and significantly reduce the numbers of writhing induced by acetic acid in mice (P<0.05). Conclusion:The CQG can inhibite the inflammation and algogenesis in mice with dose-dependent manner. |
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| Keywords: | compound qingdai granula writhing response induced by acetic acid analgesia cotton balling granulation |
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