Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin's lymphoma autografted after a first relapse. |
| |
Authors: | A Sureda M Constans A Iriondo R Arranz M D Caballero M J Vidal J Petit A López J J Lahuerta E Carreras J García-Conde J García-Lara?a R Cabrera I Jarque D Carrera J C García-Ruiz M J Pascual J Rifón J M Moraleda K Pérez-Equiza C Albó J Díaz-Mediavilla A Torres P Torres J Besalduch J Marín M V Mateos J M Fernández-Ra?ada J Sierra E Conde |
| |
Affiliation: | Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Antoni Maria i Claret, 167, 08025 Barcelona, Spain. asureda@hsp.santpau.es |
| |
Abstract: | PURPOSE: To analyse outcome and prognostic factors for overall survival (OS) and time to treatment failure (TTF) in 357 patients with Hodgkin's lymphoma (HL) undergoing an autologous stem cell transplantation (ASCT) after a first relapse and reported to the The Grupo Espanol de Linfomas/Trasplante Autologo de Medula Osea (GEL/TAMO) Cooperative Group. METHODS: Two hundred and twenty males and 137 females with a median age of 29 years were autografted in second remission (n=181), first sensitive relapse (n=148) and first resistant relapse (n=28). RESULTS: Five-year actuarial TTF and OS were of 49% +/- 3% and 57% +/- 3%. Advanced stage at diagnosis, complementary radiotherapy before ASCT, a short first complete response (CR) and detectable disease at ASCT adversely influenced TTF. Year of transplant < or =1995, bulky disease at diagnosis, a short first CR, detectable disease at ASCT and > or =1 extranodal areas involved at ASCT were adverse factors for OS. CONCLUSIONS: ASCT constitutes a therapeutic option for HL patients after a first relapse. Promising results are observed in patients with low tumour burden at diagnosis, autografted after a long CR and without detectable disease at ASCT. Innovative approaches should be pursued for patients with risk factors at relapse. |
| |
Keywords: | autologous stem cell transplantation first relapse Hodgkin's lymphoma |
本文献已被 ScienceDirect Oxford 等数据库收录! |
|