Effects of methamphetamine upon circadian rhythms in multiple unit activity inside and outside the suprachiasmatic nucleus in the golden hamster (Mesocricetus auratus) |
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Authors: | K Omata H Kawamura |
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Institution: | Department of Neuroscience, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan. |
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Abstract: | To investigate the circadian system of the golden hamster, multiple unit activity (MUA) was recorded inside and outside the suprachiasmatic nucleus (SCN). MUA inside the SCN showed a daily rhythm with a daytime peak during a 24 h light-dark cycle (LD, 12:12), whereas MUA outside the SCN revealed a nighttime peak. The phase reversal of MUA between inside and outside the SCN in the golden hamster was similar to the rat which is also a nocturnal rodent. MUA rhythms to the lighting cycle started to freerun after methamphetamine administration. This result indicates that methamphetamine may affect directly the neural circadian oscillator to induce behavioral change. |
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