The effect of short-term glucagon infusion on kidney function in normal man |
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Authors: | H. -H. Parving J. Noer H. Kehlet C. E. Mogensen P. Aa. Svendsen L. Heding |
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Affiliation: | (1) Department of Clinical Physiology, Bispebjerg Hospital, Denmark;(2) Department of Medicine F. Herlev Hospital, Denmark;(3) Hvidøre Hospital, Second University Clinic of Internal Medicine, Kommunehospitalet, Århus;(4) Steno Memorial Hospital, Denmark;(5) Novo Research Laboratories, Copenhagen, Denmark |
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Abstract: | Summary Kidney function was studied in six normal males before and during a 2 h glucagon (10 ng/kg/min) infusion. The following variables were determined during each 20 min clearance period; glomerular filtration rate (GFR), renal plasma-flow (RPF), filtration fraction (FF), urinary albumin and2-microglobulin-excretion rates. Glucagon infusion resulted in a fourfold increase in plasma glucagon concentration. The infusion induced a significant increase in GFR (+9%), FF (+ 9%) and urinary2-microglobulin excretion rate (+ 32%), (p<0.01). RPF and urinary albumin excretion rates were not significantly changed. We suggest that glucagon may contribute to the reversible kidney function alterations typically found in poorly regulated juvenile diabetes, a state with relative or absolute hyperglucagonaemia. |
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Keywords: | Diabetes functional diabetic microan-giopathy glucagon kidney function |
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