| 原花青素对心肌缺血再灌注损伤大鼠血管内皮细胞活性因子的研究 |
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| 引用本文： | 于晗,刘义.原花青素对心肌缺血再灌注损伤大鼠血管内皮细胞活性因子的研究[J].中国分子心脏病学杂志,2011,11(2). |
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| 作者姓名： | 于晗 刘义 |
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| 作者单位： | 1. 121001锦州,辽宁医学院药理学教研室;122100北票,辽宁省北票市第一人民医院循环内科
2. 辽宁医学院药理学教研室,锦州,121001 |
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| 摘 要： | 目的探讨原花青素(procyanidin,PC)对心肌缺血再灌注损伤(MIRI)大鼠血管内皮细胞活性因子的作用,为进一步研发此药对缺血性心血管疾病的防治提供依据。方法用48只雄性SD大鼠随机分成4组,即假手术组、缺血再灌注组、低剂量组(60mg/Kg)和高剂量组(120mg/Kg)。将麻醉大鼠冠脉结扎30min后,再灌注120min造成心肌损伤模型。均于结扎LAD前20min给予药物和生理盐水。结果 PC可降低再灌后血清内皮素(ET-1)浓度,升高前列环素(PGI2)含量,并升高一氧化氮(NO)的水平,使心肌细胞酶肌酸磷酸激酶(CK)和乳酸脱氢酶(LDH)漏出减少,抑制丙二醛(MDA)含量升高,提高超氧化物歧化酶(SOD)活性。结论 PC对心肌缺血再灌注损伤大鼠血管内皮细胞活性因子具有保护作用。
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| 关 键 词： | 原花青素 缺血再灌注损伤 血管内皮细胞 一氧化氮 内皮素 前列环素 |
Effects of Procyanidin on Vascular Endothelial Cell Active Factors on Myocardial Ischemia Reperfusion Injured Rats. |
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| YU han,Liu yi.Effects of Procyanidin on Vascular Endothelial Cell Active Factors on Myocardial Ischemia Reperfusion Injured Rats.[J].Molecular Cardiology of China,2011,11(2). |
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| Authors: | YU han Liu yi |
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| Institution: | YU han Liu yi Department of Pharmacology; Medical College; Liaoning 121001; China; |
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| Abstract: | Objective To study the protective effect of procyanidins on myocardial ischemia and reperfusion in rats the role of vascular endothelial cells,To further develop the drug prevention and treatment of ischemic cardiovascular disease provide a basis. Methods With 48 male SD rats were randomly divided into 4 groups, namely sham operation group , ischemia-reperfusion group, low-dose group (60mg/kg) and high-dose group (120mg/kg). Myocardial injury model was made by ligating the coronary artery for 30 min followe... |
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| Keywords: | Procyanidins Myocardial ischemia reperfusion injury Vascular endothtlial cel Nitric Oxide Endothelin Prostacyclin |
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