Interleukin-10 reduces the endotoxin-induced hyperalgesia in mice |
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| Authors: | Salim A Kanaan,Stephen Poole,Nayef E Saadé ,Suhayl Jabbur,Bared Safieh-Garabedian |
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| Affiliation: | aDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, PO Box 11-0236, Beirut, Lebanon;bDivision of Endocrinology, National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Herts EN6 3QG, England, UK;cDepartment of Physiology, Faculty of Medicine, American University of Beirut, PO Box 11-0236, Beirut, Lebanon;dDepartment of Human Morphology, Faculty of Medicine, American University of Beirut, PO Box 11-0236, Beirut, Lebanon |
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| Abstract: | In the endotoxin-induced inflammation, interleukin-10 reduced significantly, and in a dose-dependent manner, the inflammatory pain as assessed by mechanical and thermal tests. The levels of Tumour Necrosis Factor (TNF)α and NGF were upregulated at 1.5 h whereas those of IL-1β at 6 h after ET injection. IL-10 downregulated the levels of TNFα (from 4974.75±875.78 to 1008±350 pg/hind paw), NGF (from 352.9±46.7 to 33.9±2.4 pg/hind paw) and IL-1β (from 2773.88±423.96 to 1108±399.56 pg/hind paw). These data suggest that IL-10 inhibits ET-induced hyperalgesia by downregulation of TNFα, IL-1β and NGF production. |
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| Keywords: | IL-10 IL-1β TNFα NGF Hyperalgesia Inflammation |
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