介入性动脉灌注治疗胃癌术后癌性肠梗阻

目的 探讨胃癌术后腹腔转移癌性肠梗阻介入性动脉灌注化疗的疗效.方法 47例胃癌术后癌性不完全肠梗阻患者,经右侧股动脉插入血管鞘和导管、导丝,分别将导管插入腹腔动脉、肠系膜上动脉、肠系膜下动脉和双侧髂内动脉注入化疗药物,采用药物为DDP 60 mg,羟基喜树碱15 mg,5-Fu 1.0 g,化疗周期为每月动脉灌注介入化疗1次.本组病例至少灌注1次,最多13次.结果 灌注介入化疗后有效率18/47(38%),介入化疗后生存时间35 d～13个月,平均生存时间4.7个月.结论 介入灌注化疗能在短期内明显缓解癌性肠梗阻症状,延长生存时间.

Treatment of gastric carcinoma with postoperative malignant intestinal obstruction via transcatheter arterial perfusion chemotherapy

Objective To evaluate the effect of transcatheter arterial perfusion(TAP)chemotherapy for gastric carcinoma with postoperative malignant intestinal obstruction caused by abdominal cavity metastasis. Methods 47 gastric carcinoma patients with incomplete malignant intestinal obstruction after surgery received TAP chemotherapy by Seldinger method, with cisplatin, hydroxycamptothecin and FUDR per month via celiac artery, superior mesenteric artery, inferior mesenteric artery, and bilateral internal iliac arteries respectively. All patients were administered 1 to 13 times. Results The effective rate of transcatheter arterial prefusion chemotherapy was 38%(18/47)with survival period lasting from 35 days to 13 months at an average of 4.7 months. Conclusions Transcatheter arterial perfusion chemotherapy has markedly therapeutic effect in palliating treatment of malignant intestinal obstruction within short term with increase of survival time.