| MAPK在前列腺上皮内瘤中的表达及其意义 |
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| 引用本文： | 李雨成,张淑敏,白铁男,马腾骧.MAPK在前列腺上皮内瘤中的表达及其意义[J].临床泌尿外科杂志,2001,16(6):273-274. |
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| 作者姓名： | 李雨成 张淑敏 白铁男 马腾骧 |
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| 作者单位： | 天津医科大学附属第二医院泌尿外科 |
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| 摘 要： | 目的：通过研究有丝分裂活化蛋白激酶（MAPK）在前列腺上皮内瘤（PIN）组织中的表达，探讨MAPK在前列腺肿瘤形成过程中的作用。方法：采用免疫组织化学（IHC）方法对12例PIN标本和16例前列腺增生（BPH）标本进行染色检查。结果：12例PIN标本均表现了不同程度的肿瘤细胞染色，其中6例标本肿瘤细胞的细胞质有较强染色。与对照组相比较，PIN中MAPK染色指数增加了1．48倍（P＜0．05）。结论：PIN组织 中MAPLK的活性高于BPH。PIN中MAPK的过度激活可能是促进肿瘤形成的主要信号传递通路。
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| 关 键 词： | 前列腺肿瘤 蛋白激酶类 前列腺增生 前列腺上内皮瘤 MAPK |
| 文章编号： | 1001-1420(2001)06-0273-02 |
| 修稿时间： | 2000年2月13日 |
Expression of mitogen-activated protein kinase in prostatic intraepithelial neoplasia |
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| LI Yucheng,ZHANG Shumin,BAI Tienan,MA Tengxiang.Expression of mitogen-activated protein kinase in prostatic intraepithelial neoplasia[J].Journal of Clinical Urology,2001,16(6):273-274. |
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| Authors: | LI Yucheng ZHANG Shumin BAI Tienan MA Tengxiang |
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| Institution: | LI Yucheng 1 ZHANG Shumin 1 BAI Tienan 1 MA Tengxiang 1 |
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| Abstract: | Purpose:To study the expression of mitogen activated protein kinases (MAPKs) and explore whether MAPKs play an important role in the tissue of prostatic intraepithelial neoplasia (PIN).Methods:In this study,samples of 12 cases with PIN and 16 cases with benign prostate hyperplasia (BPH) were examined using immunohistochemical staining with ERK1/2 antisera.Results:A variety of levels of immunohitochemical staining for MAPK have been detected in all of 12 cases with PIN.An increased expression of MAPK in cytoplasm has been noted in 6 of 12 cases with PIN.Compared with BPH,activaty of MAPK increased 1.48 fold in PIN (P< 0.05 .Conclusions:There is a higher levels of MAPK activaty in PIN than in BPH. MAPK might be a major pathway of transducing prostatic neoplasia signals, and has promotive effect on the progression of prostatic neoplasia. |
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| Keywords: | Prostatic neoplasms Protein kinases Benign prostate hyperplasia |
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