Calcitonin gene products and the kidney |
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Authors: | A Kurtz R Muff J A Fischer |
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Institution: | (1) Physiologic Institute, University of Zürich, Switzerland;(2) Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery and Medicine, University of Zürich, Zürich, Switzerland;(3) Klinik Balgrist, Forchstrasse 340, CH-8008 Zürich, Switzerland |
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Abstract: | Summary Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation. Systemic infusion of CGRP and perfusion of isolated rat kidney reduces vascular resistance, and increases renal blood flow and glomerular filtration. CGRP stimulates renin secretion in vivo and in vitro and inhibits contraction of isolated rat mesangial cells by angiotensin II. Calcitonin does not affect vascular resistance, renal blood flow and glomerular filtration, and is less potent in stimulating renin secretion, and does not alter contraction of isolated rat mesangial cells by angiotensin II. CGRP also exerts renal tubular effects brought about probably through interaction with calcitonin receptors. To this end, increased excretion of sodium and chloride, and stimulation of urinary flow are less pronounced with CGRP than with calcitonin. Calcitonin, moreover, stimulates the fractional urinary excretion of calcium and phosphate. |
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Keywords: | Calcitonin Calcitonin gene-related peptide Renovascular effects Renotubular effects Renin secretion |
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