A Comparison of Two Oximes (HI-6 and Obidoxime) for 2-Dimethylaminoethyl-(dimethylamido)-phosphonofluoridate Poisoning

Abstract: The effects of HI-6 (1-[[[(4-aminocarbonyl) pyridinio]methoxy]methyl]-2-(hydroxyimino)-methyl]pyridinium dichloride monohydrate) on the organophosphorus agent 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate (GV) inhibited cholinesterases in blood, brain and diaphragm and the stressogenic effect of GV in rats were compared to the effects of obidoxime. In GV-poisoned rats, HI-6 had a significantly higher reactivating effect in blood and brain as well as diaphragm than had obidoxime. HI-6 also practically eliminated the stressogenic effect of the GV compound. On the other hand, hypercorticosteronaemia and increase of liver tyrosine aminotransferase activity during treatment of poisoning with obidoxime were observed. These findings demonstrate the importance of HI-6 for treatment of GV agent poisoning in rats.