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Production of parathyroid hormone-related protein by cultured human myeloma cells |
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| Authors: | Akira Suzuki Takayuki Takahashi Yoshiaki Okuno Reiko Tsuyuoka Yutaka Sasaki Manabu Fukumoto Hideki Katakami Kenkichi Kita Tsunefumi Shibuya |
| Abstract: | We examined whether or not parathyroid hormone-related protein (PTH-rP) is produced in cultured human myeloma cells. PTH-rP protein was detected in the cell extract of one (U266) of 6 myeloma cell lines examined by radioimmunoassay. Also we demonstrated the expression of PTH-rP mRNA in all of the 6 lines. These findings indicate that PTH-rP may be one of the factors responsible for the bone destruction or hypercalcemia in multiple myeloma. © 1994 Wiley-Liss, Inc. |
| Keywords: | multiple myeloma hypercalcemia PTH-rP |