Antineoplastic and Antiviral Activities of Podophyllotoxin Related Lignans |
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| Authors: | Marina Gordaliza María A Castro María D García-Grvalos Pilar Ruiz Jos M Miguel Del Corral Arturo San Feliciano |
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| Institution: | Marina Gordaliza,María A. Castro,María D. García-Grávalos,Pilar Ruiz,José M. Miguel Del Corral,Arturo San Feliciano |
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| Abstract: | 28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1μM; deoxypodophyllotoxin ( 1 ) being the most potent compound in all cases. |
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