| 急性冠状动脉综合征患者血清PAPP-A、hs-CRP水平变化及临床意义 |
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| 引用本文： | 李德柒,周乐,唐少华. 急性冠状动脉综合征患者血清PAPP-A、hs-CRP水平变化及临床意义[J]. 上海医学检验杂志, 2010, 0(2) |
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| 作者姓名： | 李德柒 周乐 唐少华 |
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| 作者单位： | 温州市第二人民医院检验科; |
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| 摘 要： | 目的探讨急性冠状动脉综合征(ACS)患者血清妊娠相关血浆蛋白A(PAPP-A)、高敏C反应蛋白(hs-CRP)的变化及临床意义。方法采用时间分辨免疫荧光分析法检测30例急性心肌梗死(AMI)患者、21例不稳定心绞痛(UAP)患者、25例稳定性心绞痛(SAP)患者和20名正常对照者血清PAPP-A,同时用乳胶增强比浊法检测血清hs-CRP。结果SAP组血清PAPP-A水平与正常对照组比较无差异(P>0.05);UAP组和AMI组血清PAPP-A水平均明显高于正常对照组和SAP组(P均<0.01),但UAP组血清PAPP-A水平与AMI组比较无差异。SAP组血清hs-CRP水平明显高于正常对照组(P<0.05);UAP组明显高于正常对照组和SAP组(P<0.01),但低于AMI组(P<0.01)。ACS组血清PAPP-A水平与血清hs-CRP水平呈正相关(r=0.53,P<0.01)。结论ACS患者血清PAPP-A与hs-CRP水平均明显升高,且hs-CRP与PAPP-A之间存在明显相关性。PAPP-A水平升高可能与动脉粥样硬化斑块的不稳定性有关,提示可作为识别ACS的早期血清学标志物。
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| 关 键 词： | 妊娠相关血浆蛋白A 高敏C反应蛋白 急性冠状动脉综合征 |
The change and clinical significance of serum pregnancy-associated plasma protein A and high sensitive C reactive protein in patients with acute coronary syndrome |
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| Abstract: | Objective To investigate the changes and the clinical significance of serum pregnancy-associated plasma protein A(PAPP-A)and high sensitive C reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS).Methods The serum levels of PAPP-A in 30 acute myocardial infarction(AMI)patients,21 unstable angina pectoris(UAP) patients,25 stable angina pectoris(SAP) patients and 20 healthy controls were determined by time-resolved fluoroimmunoassay(TRFIA);the levels of hs-CRP were determined by immune enhanc... |
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| Keywords: | Pregnancy-associated plasma protein A High sensitive C reactive protein Acute coronary syndrome |
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