Adverse effects of a single dose of (+)-sotalol in patients with mild stable asthma |
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Authors: | G Devereux K Fishwick T C Aiken S J Bourke & D J Hendrick |
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Institution: | Department of Resiratory Medicine &Regional Unit for Occupational Lung Disease, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne |
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Abstract: | Aims To investigate the effect of (+)-sotalol, which is not thought to possess clinically significant β-adrenoceptor blocking activity, on airway responsiveness in subjects with mild asthma. Methods A placebo controlled, double-blind, single dose, cross over study, evaluating the effects of oral (+)-sotalol 300 mg and oral (±)-sotalol 240 mg, on airway responsiveness, FEV1, and heart rate in 18 asthmatic volunteers with quantifiable levels of airway responsiveness. Results Compared with placebo, (+)-sotalol induced a significant increase in airway responsiveness, and a significant decrease in FEV1, but there was no significant change in heart rate. Following (±)-sotalol there was no significant effect on airway responsiveness, but there were significant decreases in FEV1 and heart rate. In one subject both (+)-sotalol and (±)-sotalol provoked a 49% decrement in FEV1, and in another there were decrements of 20% and 18%, respectively. Conclusions Despite theoretical considerations, it cannot be assumed that (+)-sotalol is safe in patients with asthma. |
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Keywords: | (+)-sotalol (±)-sotalol airway responsiveness asthma ventilatory function |
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