Mutational analysis of ras gene family in lung cancer in Thai |
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Authors: | Petmitr Songsak Wongsommart Duangdao Chaksangchaichot Panee Pakeetoot Tanett Sutinont Pantap Sirivaidyapong Patay Karalak Anant |
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Affiliation: | Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. tmspm@mahidol.ac.th |
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Abstract: | H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G right curved arrow T transversion (62%), G right curved arrow A transition (15%) and G right curved arrow C transition (15%), whereas T right curved arrow G transversion and A right curved arrow G transition were detected in N-ras mutant gene. |
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