Chromosomal location of human P-glycoprotein gene sequences |
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| Authors: | D R Bell J M Trent H F Willard J R Riordan V Ling |
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| Affiliation: | 1. Department of Chemistry, College of Science, Semnan University, Semnan, Iran;2. Faculty of Medicine, Biochemistry Department, Semnan University of Medical Sciences, Semnan, Iran;1. Biology Department, Faculty of Science, King Khalid University, 9004 Abha, Saudi Arabia;2. Cell Culture Lab, Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), Giza 12311, Egypt;3. Chemistry Department, Faculty of Science, Suez University, 43533 Suez, Egypt;4. Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany;5. Chemistry Department, Faculty of Science, Damanhour University;6. Chemistry department, College of Alwajh, Tabuk University |
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| Abstract: | Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36. |
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