长期应用他汀类药物对合并高血糖心肌梗死病人血脂及左室功能的影响

目的：观察长期应用他汀类药物对合并高血糖[包括糖调节受损（IGR）或糖尿病]心肌梗死病人血脂及心力衰竭的疗效。方法：选择59例心肌梗死患者为研究对象,给予他汀类药物调血脂治疗,分为血糖正常病人组（n=25）、高血糖病人组（n=34）。所有病人均随访2年分别于治疗前和治疗后测定TC、TG、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、左心室舒张期末内径（LVEDD）、左心室收缩期末内径（LVESD）、左心室舒张期末容积（LVEDV）、左心室收缩期末容积（LVESV）和左心室射血分数（LVEF）。观察各组患者在用药前后血脂水平、心脏功能变化。结果：长期使用他汀类药物降低正常血糖与高血糖组心肌梗死病人的TC及LDL-C水平有统计学意义（P〈0.05）。长期使用他汀类药物治疗正常血糖组和高血糖组心肌梗死病人前后LVEF均有统计学意义（P〈0.05）。结论：长期使用他汀类药物降低正常血糖组心肌梗死病人TC及LDL-C较高血糖组病人明显。长期应用他汀类药物治疗血糖正常及高血糖心肌梗死病人LVEF均有疗效。

Curative effect of long-term use of statins on blood lipid and left ventriclar function in patients with myocardial infarction accompanied by hyperglycemia

AIM: To observe curative effect of long-term use of statins on blood lipid and left ventricular function in patients with myocardial infarction accompanied by hyperglycemia. METHODS: 59 patients with myocardial infarction were randomly divided into two groups. These patients were treated with statins (euglycemia patients,n=25; hyperglycaemia patients, n=34). The levels of blood lipid, LVEDD, LVESD, LVEDV, LVESV and LVEF were measured 0 and 2 years after the onset of observation. RESULTS: The long-term use of statins decreased levels of TC and LDL-C in patients with euglycemia or hyperglycemia (P<0.01 or P<0.05), and there was a significant difference between the two groups. LVEF in two groups was statistically different (P<0.05) before and after the drugs were used. CONCLUSION: The long-term use of statins has more curative effect for patients with euglycemia than those with hyperglycemia. Left ventricular function becomes better in patients with myocardial infarction accompanied by euglycemia or hyperglycemia.