Intranasal Steroids in the Treatment of Allergy-Induced Rhinorrhea |
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Authors: | Robert A Nathan |
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Institution: | (1) Asthma and Allergy Associates, 2709 N. Tejon Street, Colorado Springs, CO 80907, USA |
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Abstract: | While nasal congestion has been identified as one of the most bothersome and prevalent symptoms of allergic rhinitis, it is
underappreciated that many patients find rhinorrhea also to be bothersome. Rhinorrhea as a symptom of allergic rhinitis virtually
never occurs alone; about 97% of patients with allergic rhinitis suffer from at least two symptoms, a finding that underscores
the advantage of treating a broad range of symptoms with a single medication. Along with sneezing and nasal obstruction, rhinorrhea
is a classic acute symptom of allergic rhinitis; it appears as a late-phase symptom as well. In this review, the characterization
and epidemiology of rhinorrhea, the pathophysiology of rhinorrhea in allergic rhinitis, the roles played by mediators in early-
and late-phase rhinorrhea, the prevalence and impact of this symptom, and the efficacy and safety of available treatment options
are all discussed in context of relevant literature. A review of the clinical studies assessing the efficacy of intranasal
corticosteroids (INS) for rhinorrhea is presented. Many clinical studies and several meta-analyses conclusively demonstrate
that, in addition to being safe and well-tolerated, INS are more effective than other agents (including oral and intranasal
antihistamines) across the spectrum of AR symptoms, including rhinorrhea and nasal congestion. |
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