First ex vivo study demonstrating that <Superscript>99m</Superscript>Tc-NTP 15-5 radiotracer binds to human articular cartilage期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

First ex vivo study demonstrating that 99mTc-NTP 15-5 radiotracer binds to human articular cartilage

Authors:	Florent Cachin Stéphane Boisgard Aurélien Vidal Marc Filaire Philippe Auzeloux Damien Culot Serge Askienazy Jean-Claude Madelmont Jean-Michel Chezal Elisabeth Miot-Noirault

Affiliation:	1.Nuclear Medicine Department,Jean Perrin Cancer Centre,Clermont-Ferrand,France;2.Orthopaedic Surgery,Gabriel Montpied University Hospital,Clermont-Ferrand,France;3.UMR 990 INSERM,Université d’Auvergne,Clermont-Ferrand,France;4.Anatomy Laboratory,Université d’Auvergne,Clermont-Ferrand,France;5.Cyclopharma Laboratoire,Saint-Beauzire,France

Abstract:	Purpose Preclinical data pointed to ^99mTc-NTP 15-5 as a good candidate for single photon emission computed tomography (SPECT) imaging of cartilaginous disease. We set out to investigate and quantify ^99mTc-NTP 15-5 ex vivo uptake by human articular cartilage relative to bone ^99mTc-hydroxymethylene diphosphonate (HMDP) radiotracer.

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