咪达唑仑和异丙酚在ICU机械通气患者镇静适用范围探讨

目的:探讨咪达唑仑和异丙酚用于ICU患者镇静的适用范围及其效果.方法:选择96例重症镇静治疗患者,随机分为咪达唑仑组和异丙酚组,比较两组起效时间、停药后苏醒时间以及两种维持镇静的效果.结果:咪达唑仑组维持剂量相对异丙酚组小(P＜0.05),药物调整次数两组无明显差异(P＞0.05).咪达唑仑组镇静起效时间长于异丙酚组(P＜0.05),停药后复苏时间长于异丙酚组(P＜0.05).结论:异丙酚适用于短时间镇静,咪达唑仑适用于长时间镇静,ICU患者镇静治疗患者应加以选择应用.

Investigate applicability of midazolam and propofol on sedative of patients with mechanical ventilation in ICU

Objective To investigate applicability and effect of midazolara and propofol on sedative of patients with mechanical ventilation in ICU.Metheds 96 cases of patients with sedative treatment were selected and randomly divided into midazolara groups and propofol groups,effeet of sedative,onset time and awakening time were contrasted between midazolam groups and propofol groups.Results maintenance dosage was lower in midazolam groups than in propofol groups （P〈0.05）,adjust number of medicine was identical between midazolam groups and propofol groups, onset time and awakening time were longer in midazolam groups than in propofol groups （P〈0.05）.Conelusions propofol was suitable to applied in short term sedative and midazolam was suitable to applied in long-playing sedative,and should be discriminate in sedative treatment on patients in ICU.