扶正固肾驱邪合剂对小鼠免疫学影响的实验观察

目的观察中药制剂扶正固肾驱邪合剂对反复呼吸道感染小鼠免疫学的影响。方法60只小鼠随机分为正常组，模型组，玉屏风组，扶正固肾驱邪合剂高、中、低剂量组。正常组和模型组分别灌服生理盐水0.5mL；扶正固肾驱邪合剂高、中、低剂量组分别灌服扶正固肾驱邪合剂0.5mL／只，分别含生药4g／mL，2g／mL，1g／mL；玉屏风组灌玉屏风口服液0.5mL／只。每日1次，4周后处死。对各组小鼠的体质量、白介素-2、CD4^＋、CD8^＋、CD4^＋／CD8^＋、CD3^＋、脾脏指数、胸腺指数进行统计比较。结果扶正固肾驱邪合剂能明显提高小鼠的体质量、白介素-2、CD4^＋、CD4^＋／CD8^＋、CD3^＋、脾脏指数、胸腺指数，降低CD8^＋，差异有统计意义（P〈0.05或P〈0.01）。结论扶正固肾驱邪合剂对以免疫功能低下为主要病因的小儿反复呼吸道感染的治疗有着广阔的前景。

The experimental observation of strengthening the body resistance reinforce the kidney eliminating the pathogenic factor mixture to the mouse immunology influence

Objective Observed the mouse immunology influence of Chinese medicine preparation strengthening the body resistance reinforce the kidney eliminating the pathogenic factor mixture on reversal respiratory tract infection. Method 60 mice were randomly divided into normal group, model group,Yu Ping-feng group, strengthening the body resistance reinforce the kidney eliminating the pathogenic factor mixture high, middle and low dose group, normal group and model group were orally administrated 0.5 mL of 0.9 % NaCI, high, middle, low dose group were orally administrated 0.5 mL of srengthening the body resistance rein- force the kidney eliminating the pathogenic factor mixture, pharmacognostic separately with 4 g/mL,2 g/mL, 1 g/mL, Yu Pingfeng group were orally administrated 0.5 mL Yu Pingfeng oral liquid. Once a day, four weeks after the death. Mice in each group for body weight, IL-2, CD4^＋, CD8^＋, CD4^＋/CD8^＋ , CD3^＋, spleen index, thymus index statistical comparison. Results Strengthening the body resistance reinforce the kidney eliminating the pathogenic factor mixture could significantly improve the body weight in mice, IL-2, CD4^＋, CD4^＋/CD8^＋, CD3^＋, spleen index, thymus index, reducing CD8^＋, had statistically significant differences （ P 〈 0.05 or P 〈 0.01 ）. Conclusion There are broad prospects for strengthening the body resistance reinforce the kidney eliminating the pathogenic factor mixture on immunocompromised children as the main cause of the treatment of recurrent respiratory tract infection.