1315例乙肝前S1抗原与乙肝HBeAg关系 |
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引用本文: | 李国宏,王晓静.1315例乙肝前S1抗原与乙肝HBeAg关系[J].现代保健,2009(18):3-4. |
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作者姓名: | 李国宏 王晓静 |
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作者单位: | [1]山东省德州市立医院,253018 [2]山东省德州市德州区妇幼保健院,253018 |
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摘 要: | 目的分析乙型肝炎病毒携带者及患者的血清前S1抗原(PreS1)与乙肝e抗原(HBeAg)的关系,评价PreS1的临床检测意义。方法筛选1315例门诊和住院治疗的乙型肝炎病毒携带者及患者的血清,采用ELISA法检测PreS1和HBV—M,并对HBeAg检测结果和PreS1检测结果不一致的样本,进一步进行HBV—DNA检测。结果HBsAg阳性标本中,PreS1阳性率为63.5%(835/1315),明显高于HBeAg的阳性率29.3%(385/1315),表明在HBV携带及患病者中,存在着较高的病毒复制。结论PreS1检测比乙肝五项尤其是HBeAg更能反映其体内HBV病毒的复制情况,具有非常重要的临床价值。PreS1作为检测体内病毒存在及繁殖情况的实验室指标,与HBV—M联合检测,对HBV感染者的早期诊断及治疗效果的动态观察具有重要意义。
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关 键 词: | 乙肝病毒 前S1抗原 HBeAg |
Clinical analysis on the relationship between PreS1 and HBeAg of 1315 cases |
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Institution: | LI Guo -hong, WANG Xiao -jing(Municipal Hospital of Dezhou , Dezhou 253018, China) |
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Abstract: | Objective To analyze relationship between PreSl and HBeAg on hepatitis B virus carriers and patients. Methods Screening of 1315 cases of chronic hepatitis B virus carriers and patients with serum,the plasma levels of PreSl and HBV - M were examined by ELISA, HBV - DNA was examined if the monitoring result of PreS1 inconsistency with HBeAg. Results With the HBsAg positive serum,the positive rate of PreS1 were 63.5% (835/1315), much bighter than the HBeAg positive of 29.3% (385/1315 ). It shows that the virus replication was higher on hepatitis B virus carriers and patients ,and PreSl can accurately reflect the condition of virus replication. Concultion PreS1 can accurately reflect the condition of virus replication, it possess a very important clinical significance. |
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Keywords: | Hepatitis B virus PreSl antigen HBeAg |
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